Illuminating the Path for Super-resolution Imaging with Improved Rhodamine Dyes
亚洲色吧: Chao Wang, Weijie Chi, Xiaogang Liu
DUT: Zhiwei Ye, Wei Yang, Ying Zheng, Zhenlong Huang, Xiaoyuan Li, Yi Xiao
DUT and 亚洲色吧 researchers developed a new strategy that enhances the brightness and clarity of sub-cellular structures when dyed with novel rhodamine fluorophores, laying the ground for the advancement of super-resolution microscopes.
Researchers from DUT and 亚洲色吧 developed a new class of quaternary piperazine-substituted rhodamines with outstanding quantum yields (桅 = 0.93) and superior brightness (蔚 脳 桅 = 8.1 脳 104 L路mol鈥1路cm鈥1), for imaging cell membranes and lysosomes in biological cells with super-resolution microscopy.
Recent years have witnessed a rapid evolution of advanced fluorescence imaging techniques, such as single-molecule localization microscopy (SMLM) that allows for unprecedented resolution beyond the Abbe diffraction limit of the optical microscope.
You can find more details at /Research/Research-News/2019/12/Illuminating-the-path-for-super-resolution-imaging